The biggest difference comes down to fabric structure and performance. A fleece sweatshirt is typically made from polyester (or a polyester blend) that’s brushed to create a soft, lofty interior designed to trap heat. A cotton sweatshirt is usually made from cotton or a cotton blend, often with a knit face and a loopback (French terry) or brushed interior, focusing more on breathability and natural comfort.
Fleece sweatshirts generally feel warmer for their weight because the brushed fibers hold onto heat efficiently. Cotton sweatshirts can be warm too—especially heavier, brushed “fleece-backed” cotton—but they tend to feel less insulating than polyester fleece when conditions get chilly or windy.
Cotton is naturally breathable and often feels comfortable across a wider range of indoor temperatures. Fleece can be cozy, but it may trap heat more quickly, which some people love for cold weather and others find too warm during active wear or heated indoor spaces.
Fleece is better at dealing with sweat in day-to-day use because polyester doesn’t absorb much water and dries faster. Cotton absorbs moisture readily, which can feel clammy if you’re sweating and can take longer to dry after washing or getting damp.
Fleece typically resists shrinking and holds its shape well, but it can pill over time (those little fuzz balls), especially with friction. Cotton can shrink if exposed to high heat and may fade gradually, but many people prefer its softer, more natural hand feel as it breaks in.
For a deeper side-by-side comparison, see the full guide here: What is the difference between fleece and cotton sweatshirts?
Cotton is often the safer pick for sensitive skin because it’s a natural fiber and usually feels less “plasticky” against the body. If choosing fleece, look for a smooth lining or a soft, high-quality knit that won’t feel scratchy.
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